Monday, July 18, 2016

An Overview of CAM: Components and Clinical Uses

INTRODUCTION
- The complementary and alternative medicine (CAM) field is complex, involving practitioners of many types, terminology that is not generally a part of allopathic or conventional healthcare, and various levels of scientific evidence guiding its use.
- The term “CAM” grew out of a movement that had defined itself as “wholisticor “holistic” medicine and has since addressed similar topics as the more recent field of integrative health and medicine.
- Of note, a broader term “healthcare” is replacing “medicine” in this discussion, allowing the involvement of many associated healthcare practitioners, including physicians, nurses, nutritionists, and pharmacists.
- Table 1 addresses some of the main characteristics of these terms, and despite considerable overlap in philosophy and approach to treatment, for the sake of simplicity of discourse, this article will refer to the overall field as CAM


- Purpose: To provide a general overview of some of the main components of CAM, or integrative health/medicine, as defined by governmental groups, academic centers, and individual associations, complete with basic definitions and some representative research trials

- Goals: For the reader to learn basic characteristics about the main CAM modalities, be exposed to some examples of related scientific evidence, and know where to go to learn more.

- It is beyond the scope of this article to explain in depth the theory or philosophical underpinnings, mechanisms of action, or applications in specific disease states, or to provide a complete review of relevant research; to these ends, the readers will be directed to other sources of information and further education.
- The CAM modalities in this article, reviewed alphabetically below, focus on the most common health practices in the United States and were selected from CAM use review articles, governmental groups, and academic research initiatives that have defined the field, including energy medicine, herbal medicine, homeopathy, mind-body medicine, nutrition, physical medicine, and a section dedicated to healthcare systems based in Asia but that are being popularly used and studied in North America.

VARIOUS CAM MODALITIES

1) Energy Medicine
- Includes numerous techniques
- In general, involves measurable, or veritable, energy and immeasurable, or putative, energy
- Veritable energies treat patients with mechanical vibrations (sound) and electromagnetic forces
- Putative energy therapies are predicated on the concept that humans are “infused with a subtle form of energy” (ie, vital energy or life force) that is not measurable by our Western scientific paradigm.
- Those who practice energy medicine believe that illness results from disturbance of these energy fields.
- Energy medicine is considered one of the more controversial CAM practices because of the difficulty in studying the energy fields and quantifying the therapeutic effects of the practices.

Example of putative energy treatment technique
a) Reiki
- Reiki uses subtle vibrational energy through light touch of the hands.
- It is believed that Reiki heals by charging affected parts of a person’s energy field with positive energy, which in turn causes the negative energy to fall away.
- The ultimate effect is to clear, straighten, and heal energy pathways, allowing the life force to flow in healthy and natural way
- This technique was developed in mid–nineteenth century Japan by Mikao Usui, a
Japanese monk who would place his hands on people for healing as part of his spiritual practice.
- Nearly a century later, Usui’s technique has evolved and become a popular healing modality throughout the world for a variety of medical conditions, though most commonly for chronic pain, cancer pain, arthritis pain, depression, and anxiety.
- There is a paucity of evidence supporting Reiki as a viable therapeutic modality, most likely because of the difficulty of studying putative energy therapies.
- One recent review concluded that the evidence is insufficient to suggest Reiki as an effective treatment for any condition, and therefore the clinical value remains unproven

b) Therapeutic touch (TT)
- Usually involves the TT practitioner moving his or her hands over the patient’s body to become familiar with the patient’s condition and enhance their natural potential to heal.
- It was started at the Theosophical Society retreat center in New York state by Dora Kunz and her colleague Dolores Krieger, PhD, RN, in 1972, and currently is most often used by nurses.
- Like Reiki, there are many clinical uses for TT, such as anxiety, stress reduction, relaxation, pain relief, and wound healing, though convincing evidence of efficacy is lacking.
- There has been 1 favorable recent review, showing efficacy for TT in treating acute and chronic pain

2) Herbal Medicine
- It is estimated that 80% of the world’s population relies on traditional medicine, largely herbs, to meet their primary healthcare needs.
- Herbal medicine infuses the current medical system not just from this popularity, but also from the multitudes of pharmaceutical products that are directly or indirectly derived from plants; examples include taxol from the Pacific yew (Taxus brevifolia), vincristine and vinblastine from the rosy periwinkle (Catharantheus roseus), and digoxin from foxglove (Digitalis spp.).
- These connections are often the basis behind healthcare practitioners’ motivation to begin the process of learning about herbal medicines

- For the clinical application of herbal medicine, practitioners of many different backgrounds base clinical recommendations on the level of evidence of efficacy and risk of use (ie, documented or theoretical possibility for adverse effects), taking into consideration what other treatment options that a particular individual has for a given medical condition (Table 2).
- The clinical integration of these factors is one way to provide structure in learning about and prescribing herbal medicines.

- One example is given for each category, though the reader is encouraged to use the many resources available (Table 3) to begin learning about other plants that can be used for medicinal purposes and their potential adverse effects, and to begin developing a referral network of herbal medicine experts, such as herbalists, naturopathic physicians, or other practitioners with advanced training in the field.


3) Homeopathy
- Homeopathy, considered one of the “Whole Medical Systems” by the National Center for Complementary and Alternative Medicine (NCCAM), is founded on the principle that a substance that causes symptoms in large doses can alleviate those symptoms when given in markedly diluted doses; in some cases, the doses are so low that little, if any, of the original substance remains, leading some practitioners to consider homeopathy one of the energy medicine modalities (the remedy is based more on remaining energetic properties of the substance than the substance itself).
- Treatment using homeopathic remedies can be determined in different ways, such as in “constitutional homeopathy,” which is based on an extensive patient intake, or in more acute prescribing, usually using combinations of individual remedies.

- The practice of homeopathy, pairing a remedy with a specific patient and his or her specific set of symptoms, inherently makes it difficult to study in the conventional sense of a randomized, placebo-controlled trial.
- Nonetheless, some clinical trials have been undertaken to examine the use of one of several homeopathic remedies for a given clinical entity, or the effect of a single homeopathic product on a group of patients.
- For example, one of the first research trials on this topic randomized 81 children with acute diarrhea to receive either one of 18 individualized homeopathic remedies or placebo.
- The homeopathic treatment group showed a statistically significant decrease in the number of days until there were less than 3 unformed stools.
- Homeopathy is commonly studied using numerous individualized treatments in this way

- Since some of this initial research, other applications for homeopathy have been analyzed in clinical trials, including postoperative pain, sinusitis, injuries, skin conditions, and ADHD, 29 among many others.
- The results have been mixed, with some trials showing no effect.
- The appearance of meta-analyses should begin to shed light on the medical conditions for which homeopathy is most effective
- One of the benefits often mentioned for the use of homeopathy is the almost complete absence of adverse effects; remedies are extreme dilutions of single substances, leaving mostly an “essence” of the compound, and such a low dose is considered very unlikely to cause an adverse effect.
- This advantage of homeopathic remedies makes them very interesting candidates for adjunctive therapy in combination with conventional treatment, as well as for clinical entities with a paucity of convincing allopathic medical options
Note on Homeopathy (ZYL):
- One meta-analysis published in Lancet in year 1997 by Linde et al, concluded that “there is insufficient evidence that homoeopathy is clearly efficacious for any single clinical condition” DOI: 10.1016/S0140-6736(97)02293-9
- Another more recent meta-analysis of RCTs by Mathie et al (2014) concluded that “Medicines prescribed in individualised homeopathy may have small, specific treatment effects. The low or unclear overall quality of the evidence prompts caution in interpreting the findings. New high-quality RCT research is necessary to enable more decisive interpretation”. DOI: 10.1186/2046-4053-3-142

4) Mind-Body Medicine
- Defined as treatments that focus “on the interactions among the brain, mind, body, and behavior, and on the powerful ways in which emotional, mental, social, spiritual, and behavioral factors can directly affect health.”
- The physiologic theory underlying mind–body medicine is the brain and central nervous system’s modulation of immunologic, endocrine, and autonomic functioning, which in turn influences states of health and disease.
- A central focus has been the deleterious effects of the stress response; mind–body modalities seek to alter this process via various forms of stress management, relaxation, coping skills training, and cognitive behavioral techniques combined with health and disease-specific education.
- There are numerous mind–body techniques; the most commonly used and largely substantiated modalities include cognitive behavioral therapy, hypnosis, biofeedback, autogenic training, progressive muscle relaxation, guided imagery, and meditation

- Clinical research is beginning to support the use of mind-body techniques as a component of treatment for arthritis, chronic low-back pain, coronary artery disease and cardiac rehabilitation, headaches, hypertension, insomnia, incontinence, disease treatment–related symptoms of cancer, and for improving postsurgical outcomes.
- Other research has explored possible mechanisms of action in the above conditions.
- However, it should be noted that comprehensive analysis of mind-body medicine has been difficult because of poor methodological quality of studies and reporting biases

Example of application of mind-body medicine
a) Cardiovascular disease and hypertension
- In one study, when incorporated into cardiac rehabilitation programs, mind–body therapies have demonstrated reductions in mortality and recurrent cardiac events along with improvements in diet, exercise, weight, smoking, cholesterol, and blood pressure
- A recent 2-part article discusses the evidence relating chronic stress, insulin resistance, and cardiovascular disease to the potential role of mind–body therapies in disrupting these pathological processes. (Part I: Innes et al. Alt Ther Health Med. 2007;13:46-52. Part II: Innes et al. Alt Ther Health Med. 2007;13:44-51)
- Two recent systematic review have demonstrated significant reductions in both systolic and diastolic blood pressure associated with the practice of transcendental meditation. (Rainforth et al. Curr Hypertens Rep. 2007;9:520-528 & Anderson et al. Am J Hypertenstion. 2008; 21:310-316)
- The use of biofeedback in patients with congestive heart failure has been shown to improve cardiac output, entrain slower breathing, and improve exercise tolerance. Further, the relaxation response induced via biofeedback serves to decrease activation of the sympathetic nervous system and, much like the action of β-blockers, may facilitate remodeling of the heart

b) Oncology Care
- A significant amount of literature has demonstrated that mind-body therapies are beneficial for reducing physical and emotional symptoms and improving quality of life among cancer survivors. For example, psychosocial stress may have a role in physical and mental health status and outcomes in cancer patients.
- Specifically, symptoms related to stress include anxiety, depression, traumatic stress symptoms, fatigue, pain, impaired sleep, increased morbidity and mortality, decreased immune function, increased relapse, and decreased quality of life.
- Mind-body techniques that function to address this stress can be powerful adjuncts to regular oncology care, thereby serving to improve health status, disease outcome, and overall quality of life. Mechanism of action and efficacy data exist to support the benefit of these therapies. (Monti et al. Cancer. 2008;112(11 suppl):2607-2616)

c) Pain-related disorders
- Research has also investigated the role of mind–body therapies in pain-related disorders.
- A review examining the use of biofeedback for tension and migraine headaches demonstrated a reduction in headache frequency, medication use, and associated depression and anxiety. (Nestoriuc et al. App Psychophysiol Biofeedback. 2008;33:125-140)
- For patients with chronic pain, various techniques such as hypnosis, meditation, biofeedback, guided imagery, and cognitive behavioral therapy have all demonstrated efficacy and share a common goal of instilling self-control and self-management. Among these techniques, cognitive behavioral therapy is the most extensively studied and supported approach. (Turk et al. Can J Psychiatry. 2008;53:213-223)

d) Other potential applications
- Additional promising areas of inquiry that have recently been reviewed involve the use of mind–body techniques to reduce seizure frequency and improve quality of life in patients with epilepsy; to modulate perceived stress, mood, and perinatal outcomes; to manipulate the interaction of brain and immune system, hereby altering the course of autoimmune disease; in the treatment of depression and anxiety; and in the treatment of irritable bowel syndrome in adults

5) Nutrition
- Dietary modification is a cornerstone of CAM for both prevention and treatment of various conditions.
- It is well known that food choices have a large impact on health and that specific nutrition interventions can significantly affect many diseases.
- One approach to the large topic of nutrition is to focus on general diets or types of food choices and healthful eating
- The Mediterranean Diet and the Anti-inflammatory Diet (AID), for which there is some of the best clinical data in favor of disease modification and health promotion, will be discussed.

a) Mediterranean Diet
- The Mediterranean Diet is a composite of the eating styles of Spain, southern France, Italy, Greece, Crete, and parts of the Middle East. This diet rose to Western popularity beginning in the 1940s, but it was the physiologist Ancel Keys in 1975 who pioneered the investigation of
the relationship between dietary fat and serum cholesterol and the risk of coronary heart disease.
- This diet includes a high intake of fruit, vegetables (mostly wild plants), nuts, cereals, olive oil, a moderate intake of mostly red wine, and fish, with a lower intake of meat and dairy products
- Analysis of this dietary pattern shows a number of protective substances, such as selenium, glutathione, a balanced ratio of ω-6 to ω-3 fatty acids, high amounts of fiber, antioxidant phytochemicals (especially resveratrol from wine and polyphenols from olive oil), and vitamins E and C, some of which have been shown to be associated with lower risk of cancer and with other health benefits.
- Multiple small studies have been published that demonstrate the health benefits of adhering to the Mediterranean Diet, but there are 2 larger-scale studies that prove its efficacy on a population level.
- A randomized, secondary-prevention trial known as the Lyon Diet Heart Study tested whether the Mediterranean Diet may reduce the rate of recurrence after a first myocardial infarction (MI). The study confirmed the protective effect of the Mediterranean Diet and its ability to prevent recurrence of MI up to 4 years after the first infarction
- The second study, the National Institutes of Health American Association of Retired Persons (AARP) Diet and Health Study, investigated the effect of the Mediterranean dietary pattern on mortality. Men (n = 214,284) and women (n = 166,012) ages 50-71 participated in this prospective study and were followed for 10 years. The results revealed that adherence to the Mediterranean diet was associated with reduced all-cause and cause-specific mortality

b) The Anti-inflammatory Diet (AID)
- The AID is not intended as a temporary weight loss program, but rather as a way of selecting and preparing foods to help decrease an unhealthful inflammatory response.
- Focuses on the types of carbohydrates and fats, promotes the intake of dietary antioxidants by eating fruits and vegetables from the full color spectrum, and encourages changing from coffee to green tea (Camellia sinensis) to take advantage of the antioxidant polyphenols in green tea, and recommends that people increase consumption of culinary spices with anti-inflammatory properties such as ginger, turmeric, and garlic.
- By focusing on the types of fat intake, the AID involves decreasing intake of saturated fat and trans fatty acids, and decreasing the ω-6 fatty acid intake and increase ω-3 fatty acid intake to approach a 1:1 ratio of ω-6:ω-3.
- With respect to carbohydrate types, the AID involves more low-glycemic index (GI) carbohydrates and less high-GI carbohydrates; the goal is to moderate serum blood glucose spikes, leading to fewer compensatory insulin increases and the associated inflammatory response thought to result from high insulin levels
- The majority of the research pertaining to the AID as a whole centers around ω-3 fatty acids. When ω-3 fatty acids (vs ω-6 fatty acids) are preferentially metabolized by cyclooxegnase and lipoxegnase, less arachadonic acid is formed and the creation of less pro-inflammatory prostaglandins and leukotrienes is promoted. The overall result of an ω-6 to ω-3 ratio closer to 1:1 (more typical in the Western diet is 10-20:1) is a shift to a less inflammatory physiological state.

(Note from ZYL: Personally, I disagree that nutrition be categorized under CAM. In my opinion, CAM are treatment that lacks extensive research, and nonessential (the ‘unused’ of CAM will not put the patient at risk of worsening of disease if proper treatment is given under modern medicine). However, nutrition (medical nutrition therapy) is derived from extensive research and is indispensable in the management of diseases such as diabetes, hypertension, cardiovascular diseases etc. What do you think?)

6) Physical Medicine
- Called “body-based practices” by NCCAM, physical medicine and manual therapy are general terms used to describe treatments aimed at affecting the structure or function of some part of the body, such as soft tissue (muscle, fascia, ligaments, tendons) or bones.
- Examples of modalities that fall under physical medicine are chiropractic, massage, and osteopathic manipulation; there are other techniques that could be listed under these modalities, such as craniosacral therapy and muscle-energy release
- Practitioners with various levels of training are involved in physical medicine, including chiropractors (doctors of chiropractic, or DC), massage therapists (licensed massage therapists, or LMT), osteopathic physicians (doctors of osteopathy, or DO), naturopathic physicians (naturopathic doctors, or ND), and allopathic healthcare providers who have obtained additional training.
- An overlap with some treatments that are considered within the realm of conventional medicine, such as physical and occupational therapy, often exists; there are state-to-state variations in the scope of practice of the different physical medicine practitioners that may affect which specific techniques fall into the realm of which particular practitioner
- The decision about whether to use physical medicine treatments or refer a patient for physical medicine depends on the physical medicine practitioner’s specialties and particular skill set (does it overlap with the patient’s complaints?), as well as, after an examination including palpation of the affected joint(s) or muscle, whether the physical medicine specialist sees a possible pairing of a specific treatment modality with that patient’s health condition. Furthermore, numerous clinical trials, some of which are reviewed below, are attempting to clarify which diagnoses fit best with which modalities.

- Most of the research has been on spinal manipulation for various musculoskeletal complaints.
- For acute or chronic low-back pain, one review of 39 trials found that spinal manipulation did not appear to be statistically superior to analgesics, general medical care, physical therapy, exercises, or classes about a healthful back care regimen (“back school”), taking into account methodological quality, the training of the practitioner, and other therapies used.
- For neck pain, a review of 4 clinical trials found that for neck pain of various etiologies, there was no difference between exercise therapy and chiropractic spinal manipulation; the authors clarified that the paucity of research on manual medicine makes it difficult to say that manual medicine is as effective as exercise regimens. None of the trials were sham controlled, compromising the research quality
- For chronic headaches, one review of 9 trials that included 683 people demonstrated the challenges of pooling physical medicine data to provide clinical recommendations.
- The studies involved varied in methodological quality and examined headaches of different etiologies, but the authors were able to draw the preliminary conclusions that spinal manipulation appeared to be better than massage for cerviogenic headaches, similar to tricyclic antidepressants for chronic tension headaches, and not additionally useful from massage for episodic tension headaches

- Researchers have also examined the use of massage for low-back pain and functioning; some of the trials compare massage to sham treatments, whereas other trials suffer from methodological flaws. Nonetheless, massage appears to be similar to exercise and better than spinal manipulation, physical therapy, self-care instruction, acupuncture, and relaxation therapy; these results do not hold for reflexology of the feet

- In summary, research has begun to guide the clinical use of the different physical medicine modalities. For example, the results have been mixed for which modality is the most effective for acute low-back pain, but most modalities have consistently shown benefit for chronic low-back pain. Also, spinal manipulation has shown benefit or neck pain and cervicogenic headaches.

7) Ayurveda, Traditional Chinese Medicine, and Kampo Medicine
- In general, there are interesting differences in philosophy, diagnosis, and treatment between these 3 systems, often referred to collectively as “Eastern” medicine, and healthcare provision in the United States and Europe, or “Western” medicine
- For example, Western medicine’s concept of disease is pathogen based, with a specific treatment targeted to the specific pathogen.
- Eastern medicine is more system based, and disease is understood as a physiological manifestation of a disturbance or weakening of the body; in this respect, prevention is often a key component of Eastern medicine
- Additionally, treatments tend to be individualized to the patient, and the presenting symptoms are adjusted as symptoms change and may incorporate multiple modalities as well as components of herbal formulae
- It follows that isolating a single element from an entire system of treatment may yield very different results than when examined within a holistic treatment context.
- This background helps to explain the variety of research results, ranging from evidence of potential benefit to inconsistent or no clear evidence of efficacy; this variety is often a result of a lack of high-quality randomized controlled trials and the difficulty of designing studies that take into account Eastern understanding of cause of disease, classification of disease, and approach to patient treatment.

a) Ayurveda
- Ayurvedic medicine is an ancient system of medicine, with origins approximately 5000 years ago.
- A key concept in understanding health and disease in Ayurvedic medicine is the tri-dosha theory.
- The 3 doshas, or energies, are vata, pitta, and kapha.
- Each person is endowed with a particular constitution, or prakruti, that is some combination of these doshas.
- There may be 1 prominent dosha, co-dominance of 2 doshas, or occasionally an equal presence of all 3.
- One’s prakruti is said to govern responses to mental and physiological occurrences
- As such, disease is understood to result from the combination of an imbalance of the doshas, low immune function, and the presence of toxins, or ama.
- Therefore, an understanding of one’s prakruti enables lifestyle changes to be implemented to prevent manifestation of disease.
- Similarly, a balancing of the doshas is an integral part of treating disease that is already present

- Ayurvedic treatment modalities are employed to remove the cause of imbalance or disease, strengthen the body’s ability to eliminate toxins, and reestablish a state of balance.
- Detoxifying the body proceeds via the use of active purging and purifying measures (panchakarma) or via the use of herbs and fasting
- During and after this process, proper lifestyle, diet, and exercise for one’s constitution must be maintained.
- Other modalities include pranayama (breathing exercises), yoga, meditation, gemstones, crystals, metals, sound, and color.
- Some of the treatment approaches in Ayurvedic medicine have been subject to research studies.
- For example, many Ayurvedic herbs now have data showing varying levels of efficacy.
- The herb curcumin is being studied in many disease models, including multiple myeloma, pancreatic cancer, myelodysplasia, monoclonal gammopathy of unknown significance, colon cancer, Barrett’s metaplasia, ulcerative colitis, primary sclerosing cholangitis, Alzheimer’s disease, and psoriasis.
- Also, yoga, another treatment from the Ayurvedic tradition, has been investigated for many conditions, including menopause, cancer, and depression.

b) Traditional Chinese Medicine (TCM)
- The practice of TCM began approximately 2000-3000 years ago and has its roots in Taoist, Buddhist, and Neo-Confucian philosophy.
- Two central concepts of TCM are yin-yang and wu xing

- TCM theory holds that the universe, including the body, is composed of the 2 opposite components yin and yang.
- Yin is inactive, descending, internal, cold, and dark.
- Yang is active, ascending, external, hot, and bright.
- Based on these characteristics, the body’s physiological functions and organs as well as signs and symptoms can be divided into yin and yang.

- Wu xing is the theory that all things in the universe are composed of 5 elements—wood, fire, earth, metal, and water—each associated with specific relationships to the others.
- Each of the internal organs represents an element, and the organs interact according to these characteristic relationships.
- Harmony is maintained through the proper function of the internal organs (zang-fu) and blood, body fluids, and qi (vital energy), which circulate through the meridian (jing) and collateral (luo) system

- Disease manifests from a disturbance in the body’s harmony, or an imbalance in yin, yang, and wu xing.
- This disturbance manifests as disruption in qi, blood, body fluids, or the internal organs, producing certain symptoms.
- Causes of imbalance and disease are classified as internal, external, and other.
- External factors include excessive wind, cold, heat, dampness, dryness, and fire.
- Internal factors are excesses of the emotions.
- Other factors include diet, taxation fatigue, trauma, sexual activity, and parasites

- A central theme of TCM treatment is prevention of disease through proper lifestyle.
- When a disease is present, treatment for symptomatic relief may be given, and then attention is focused on addressing the root cause.
- Treatment modalities include herbs; acupuncture; moxibustion (burning the herb moxa, or mugwort, at acupuncture points either directly on the skin, held over the skin, or attached to inserted acupuncture needles); massage and acupressure (tui na); mind–body techniques (qigong and tai ji quan); and dietary therapy.
- The research literature for TCM modalities is extensive, including both foreign-language journals and, more recently, English-language journals.
- A complete review of the research is beyond the scope of this article, but Table 4 lists some of the current literature based on individual studies as well as systematic reviews.
- In addition to the difficulties in interpreting TCM research as discussed above, some clinical trials have been found to lack randomization, further compromising the validity and applicability of the research results



c) Kampo
- Kampo, or Traditional Japanese Medicine, is largely derived from the introduction of TCM to Japan and has been in practice for approximately 1500 years.
- Accordingly, its philosophy is similar to that of TCM, but it has a more practical symptom-based approach largely because of a later Western medical influence and the necessity of validating treatment to be included in coverage by Japan’s national health insurance (NHI) program.
- Therefore, although disease is understood to be a result of the imbalance of the body’s systems, diagnosis and treatment focuses mainly on the symptoms, or Sho, and the corresponding herbs used to treat such symptoms.
- Treatment is primarily herbal, with more than 200 herbs in use, 148 of which are covered by the NHI program.
- As in TCM, acupuncture, acupressure (shiatsu), and moxibustion  may also be part of a patient’s treatment plan
- Of the 3 systems of medicine discussed in this section, Kampo has the least amount of published research regarding evaluation of its efficacy in treating disease as classified in Western terms.
- Much research has been devoted to the chemical analysis and more recently, to the physiological, biochemical, pharmacological, and immunological effects of Kampo herbs

CONCLUSIONS
- This article reviewed several of the main CAM modalities, providing basic background and some of the relevant research studies.
- Complementary and alternative medicine is composed of many different treatment techniques and approaches, is very popular in the United States, and is becoming part of the provider-patient discussion in clinics of all types.

- The evidence for or against its use is accumulating; some of the journals and other sources listed here will help practitioners interested in CAM to further delve into the topic.

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